Highway 627 west of Edmonton was impassable Friday evening after what RCMP called a serious collision.
The crash happened near Highway 627 and Range Road 265.
Four people were taken to hospital with non-life threatening injuries.
The area was closed for emergency response and Stony Plain RCMP had detours in place for several hours. It reopened around before 10:30 p.m.
A collision investigation is underway.